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<\/p>\nAn understanding of cells and cell behavior is a critically important component of disease diagnosis and treatment. But some diseases can be complex in nature, with a variety of factors and circumstances impacting their emergence and severity.<\/p>\n
Effective disease analysis often requires an understanding that goes beyond isolated cell behavior. Genes, the environments in which cell processes operate, the impact of patient characteristics, and racial and ethnic variables all can have an important impact.<\/p>\n
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Photo Credit: Getty Images\/Hero Images<\/em><\/p><\/blockquote>\n
An understanding of the signals and symptoms of alterations in cellular processes is a critical step in the diagnosis and treatment of many diseases. For APRNs, this understanding can also help educate patients and guide them through their treatment plans.\n<\/p>\n
In this Assignment, you examine a case study and analyze the symptoms presented. You identify cell, gene, and\/or process elements that may be factors in the diagnosis, and you explain the implications to patient health.<\/p>\n
To prepare:<\/strong><\/p>\n
By Day 1 of this week, you will be assigned to a specific case study for this Case Study Assignment. Please see the \u201cCourse Announcements\u201d section of the classroom for your assignment from your Instructor.<\/p>\n
The Assignment (1- to 2-page case study analysis)<\/h4>\n
Develop a 1- to 2-page case study analysis in which you:<\/p>\n
\n
- Explain why you think the patient presented the symptoms described.<\/li>\n
- Identify the genes that may be associated with the development of the disease.<\/li>\n
- Explain the process of immunosuppression and the effect it has on body systems.<\/li>\n<\/ul>\n
By Day 7 of Week 2<\/h5>\n
Submit<\/strong> your Case Study Analysis Assignment by Day 7 of Week 2<\/strong>.<\/p>\n
Reminder:<\/strong> The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. The sample paper provided at the Walden Writing Center provides an example of those required elements (available at https:\/\/academicguides.waldenu.edu\/writingcenter\/templates<\/a>). All papers submitted must use this formatting.<\/p>\n
CASE STUDY<\/p>\n
Scenario 4:<\/strong>\u00a0A 65-year-old obese African American male patient presents to his HCP with crampy left lower quadrant pain, constipation, and fevers to 101\u02da F. He has had multiple episodes like this one over the past 15 years and they always responded to bowel rest and oral antibiotics. He has refused to have the recommended colonoscopy even with his history of chronic inflammatory bowel disease (diverticulitis), sedentary lifestyle, and diet lacking in fiber. His paternal grandfather died of colon cancer back in the 1950s as well. He finally underwent colonoscopy after his acute diverticulitis resolved. Colonoscopy revealed multiple polyps that were retrieved, and the pathology was positive for adenocarcinoma of the colon.\u00a0<\/p>\n
<\/p>\n
Learning Resources<\/h1>\n
Required Readings<\/strong> (click to expand\/reduce)<\/a><\/p>\n
McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children<\/em> (8th ed.). St. Louis, MO: Mosby\/Elsevier.
\n\u00a0Chapter 1: Cellular Biology; Summary Review
\n\u00a0Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents(pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review
\nChapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases,
\nChapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review
\nChapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review<\/p>\nChapter 7: Innate Immunity: Inflammation and Wound Healing
\nChapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review
\nChapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review
\nChapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review
\nChapter 11: Stress and Disease (stop at Stress, illness & coping);<\/strong> Summary Review
\nChapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review
\nChapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review\u00a0Note<\/strong>:\u00a0You previously read these chapters in Week 1 and you are encouraged to review once again for this week.<\/p><\/blockquote>\nJustiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls<\/em>. Treasure Island, FL: StatPearls Publishing. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513315\/<\/a>
\n\u200bCredit Line<\/strong>: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513315\/. Used with permission of Stat Pearls.<\/a>
\n Note<\/strong>: This article was presented in the Week 1 resources. If you read it previously you are encouraged to review it this week.<\/a><\/p><\/blockquote>\nRequired Media<\/strong> (click to expand\/reduce)<\/a><\/p>\n
Foundational Concepts of Cellular Pathophysiology – Week 2<\/strong>\u00a0(8m)
\nAccessible player –Downloads–Download Video w\/CCDownload AudioDownload Transcript<\/p><\/blockquote>\nImmunity and Inflammation<\/strong><\/h6>\n
Khan Academy (2010, February 24). Inflammatory response | Human anatomy and physiology\u00a0<\/em> | Health & medicine<\/em> [Video file]. Retrieved from https:\/\/www.youtube.com\/watch?v=FXSuEIMrPQk\u00a0\u00a0<\/a>
\nNote<\/strong>: The approximate length of the media program is 14 minutes.<\/a><\/p><\/blockquote>\nSoo, P. (2018, July 28). Pathophysiology Ch 10 alterations in immune function<\/em> [Video file]. Retrieved from https:\/\/www.youtube.com\/watch?v=Jz0wx1-jTds \u00a0\u00a0<\/a>
\nNote<\/strong>: The approximate length of the media program is 37 minutes.<\/a><\/p><\/blockquote>\nAcid-Base Balance #1<\/strong><\/h6>\n
MedCram. (2012, April 28). Medical acid base balance, disorders & ABGs explained clearly<\/em> [Video file]. Retrieved from https:\/\/www.youtube.com\/watch?v=4wMEMhvrQxE<\/a>
\nNote<\/strong>: The approximate length of the media program is 13 minutes.<\/a><\/p><\/blockquote>\nAcid-Base Balance #2<\/strong><\/h6>\n
MedCram. (2012, April 29). Medical acid base balance, disorders & ABGs explained clearly | 2 of 8 <\/em>[Video file]. Retrieved from https:\/\/www.youtube.com\/watch?v=GmEeKVTpOKI\u00a0\u00a0<\/a>
\nNote<\/strong>: The approximate length of the media program is 15 minutes.<\/a><\/p><\/blockquote>\nHyponatremia<\/strong><\/h6>\n
MedCram. (2017, December 23). Hyponatremia explained clearly [LK1] (remastered) \u2013 Electrolyte imbalances<\/em> [Video file]. Retrieved from https:\/\/www.youtube.com\/watch?v=bLajK5Vy55M<\/a>
\nNote<\/strong>: The approximate length of the media program is 15 minutes.<\/a><\/p><\/blockquote>\nOnline Media from\u202fPathophysiology: The Biologic Basis for Disease in Adults and Children<\/h3>\n
In addition to this week\u2019s media, it is highly recommended that you access and view the resources included with the course text, Pathophysiology: The Biologic Basis for Disease in Adults and Children<\/em>. Focus on the videos and animations in Chapters 3, 7, and 8 that relate to alterations in immunity, hyponatremia, and acid\/base balance.<\/p>\n
Note<\/strong><\/em>: To access the online resources included with the text, you need to complete the FREE online registration that is located at\u00a0<\/em>https:\/\/evolve.elsevier.com\/cs\/store?role=student<\/em><\/a><\/p><\/blockquote>\n
To Register to View the Content<\/h4>\n
\n
- Go to\u00a0https:\/\/evolve.elsevier.com\/cs\/store?role=student<\/a><\/li>\n
- Enter the name of the textbook, Pathophysiology: The Biologic Basis for Disease in Adults and Children<\/em>, or ISBN 9780323654395 (name of text without the edition number) in the Search textbox.<\/li>\n
- Complete the registration process.<\/li>\n<\/ol>\n
To View the Content for This Text<\/h4>\n
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