Due to aging and alterations of disease, the cellular structure of the body changes across the lifespan—from pediatrics to geriatrics. As a result, body systems begin to function differently and may react to drugs differently through pharmacokinetic and pharmacodynamic processes. In pediatric and geriatric patients, the body absorbs, distributes, metabolizes, and excretes drugs differently than the average adult’s body. Since the dosing guidelines for most drugs are not written to account for these differences, the potential for adverse reactions in pediatric and geriatric patients increases. When prescribing drugs to pediatric and geriatric patients, health care providers have to weigh benefits against potential harmful effects.
October 18, 2021Univariate statistics were generated for all variables in the data set. Most data were treated as categorical, and most bivariate analyses were conducted with chi square analysis or Fisher’s exact test, as appropriate. Multivariate analyses were conducted using logistic regression. Analyses were guided by a priori hypotheses to limit type II error, and they were conducted using two-sided tests with α =.05. Analyses were performed using SAS, version 9.1. Results Participants
October 18, 2021
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Molloy et al: See attached article
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